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Seizure has been estimated to occur in association with clozaril use at a cumulative incidence at one year of approximately 5 , based on the occurrence of one or more seizures in 61 of 1743 patients exposed to clozaril during its clinical testing prior to domestic marketing.

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Patients with a history of epilepsy should be closely observed during Clozaril therapy since dose-related convulsions have been reportedIn such casesthe dose should be reducedsee section 4.2andif necessaryan anti-convulsant treatment should be initiated.

As with other antipsychoticscaution should be exercised when clozapine is prescribed with medicines known to increase QTc intervalor causing electrolyte imbalance.

The risk of QT prolongation may be increased if you have certain medical conditions or are taking other drugs that may affect the heart rhythmBefore using clozapinetell your doctor or pharmacist of all the drugs you take and if you have any of the following conditionscertain heart problemsheart failureslow heartbeatQT prolongation in the EKGfamily history of certain heart problemsQT prolongation in the EKGsudden cardiac death

Clozapine decreases hallucinations and helps prevent suicide in people who are likely to try to harm themselvesIt helps you to think more clearly and positively about yourselffeel less nervousand take part in everyday life.

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patients with ben require a different anc algorithm for clozaril management due to their lower baseline anc levels.

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